INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH BHOPAL

 

Name: Dr. Sathish Narayanan
Designation: Assistant Professor
Department: Biology
E-Mail: sathishn@iiserb.ac.in
Phone: +91-755-4092342
Fax: +91-755-4092392

Academic Profile:

  • Assistant Professor (May 2011- Present), Biology, Indian Institute of Science Education and Research, Bhopal, India.

  • Post-doc. (2005-2010). Research Area: Tegument proteins of Kaposi’s sarcoma-associated herpesvirus (KSHV).  Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

  • Ph.D. (2005). Research Area: Human papillomavirus (HPV) and its association with cervical neoplasia among Indian women.  Department of Clinical Virology, Christian Medical College (C.M.C), Vellore, Tamilnadu, India.   

Research Interest:

  • To comprehend the tegument architecture of human herpesviruses. 
  • To delineate the functional roles of human herpesviral tegument proteins in:         
    • Transportation of both the incoming viral particles to the nucleus and the assembled viral particles towards egress. 
    • Evasion of anti viral innate immune responses, specifically involving the interferon regulatory factor (IRF) -3 and -7 mediated type I IFN induction and signaling pathways.

Awards:

  • Gold medal for the Best Outgoing Student in Bachelor’s degree: B.Sc (Medical Laboratory Technology), Christian Medical College (C.M.C), Vellore, Tamilnadu, India. 
  • Gold Medal for the Best Outgoing Student in Master’s degree: M.Sc (Medical Microbiology), Christian Medical College (C.M.C), Vellore, Tamilnadu, India.   
  • UNESCO-ASM Travel Award Fellowship (2004).  Fellowship at the Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

Selected Publications:

Post doctoral:

  1. Sathish N, Zhu FX, Golub EE, Liang Q and Yuan Y.  Mechanisms of auto-inhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi’s sarcoma-associated herpesvirus protein ORF45.  J. Biol. Chem. 2011; 286: 746-756. 
  2. Wang Y, Sathish N, Hollow C and Yuan Y.  Functional characterization of Kaposi’s sarcoma-associated herpesvirus open reading frame K8 by bacterial artificial chromosome-based mutagenesis.  J. Virol. 2011; 85: 1943-1957.
  3. Sathish N and Yuan Y.  Functional characterization of Kaposi’s sarcoma-associated herpesvirus small capsid protein by bacterial artificial chromosome-based mutagenesis.  Virology. 2010; 407: 306-318.   
  4. Zhu FX, Sathish N and Yuan Y.  Antagonism of host antiviral responses by Kaposi’s sarcoma-associated herpesvirus tegument protein ORF45.  PLos One. 2010; 5: e10573.   
  5. Sathish N, Zhu FX and Yuan Y.  Kaposi’s Sarcoma-associated herpesvirus ORF45 interacts with kinesin-2 transporting viral capsid-tegument complexes along  microtubules. PLoS Pathog. 2009; 5: e1000332.   
  6. Ramona R, Sathish N, Li Y and Yuan Y. Virion-wide protein interactions of Kaposi's sarcoma-associated herpesvirus.  J. Virol. 2008; 82: 4742-50.

Doctoral:

  1. Sathish N, Abraham P, Peedicayil A, Sridharan G, Chandy G.  HPV 16 E6 sequence variations in Indian patients with cervical neoplasia. Cancer. Letters. 2005; 229: 93-99.
  2. Sathish N, Abraham P, Peedicayil A, Sridharan G, Shaji RV and Chandy G.  E2 sequence variations of HPV 16 among patients with cervical neoplasia seen in the Indian subcontinent. Gynecol. Oncol. 2004; 95:363-369.
  3. Sathish N, Abraham P, Peedicayil A, Sridharan G, John S and Chandy G.  HPV 16 E6/E7 transcript and E2 gene status in patients with cervical neoplasia. Mol. Diagn. 2004; 8: 57-64.
  4. Sathish N, Abraham P, Peedicayil A, Sridharan G, John S, Shaji RV and Chandy G.  HPV DNA in plasma of patients with cervical carcinoma. J. Clin. Virol. 2004; 31:204-209 (among the top 25 hottest articles in the October-December 2004 volumes).
  5. Sathish N, Vijayakumar TS, Abraham P and Sridharan G. Dengue fever: It’s laboratory diagnosis, with special emphasis on IgM detection.  WHO Dengue Bulletin. 2003, Volume 27. (Invited article from World Health Organization [WHO] South East Asian Division). 

 
 



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