INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH BHOPAL

 

Name: Dr. Prasanta Ghorai
Designation: Assistant Professor
Department: Chemistry
E-Mail: pghorai@iiserbhopal.ac.in
Phone: +91-755-4092325
Fax: +91-755-4092392

Academic Profile:

  • Assistant Professor (March 2009-), Chemistry, Indian Institute of Science Education and Research, Bhopal, India.
  • Post-doc. Oct. 2005 – Feb. 2009 University of Nebraska-Lincoln, USA.
  • Ph.D. 2005 University of Regensburg, Germany.

Research Interest:

  • Our research program aimed toward the development of catalysts, catalytic reactions and methods for organic synthesis. However, our primary focus will be development of New Chiral Catalytic System for Asymmetric Synthesis. Ultimately, we are interested in using these methods to address problems in the synthesis of complex molecules possessing interesting structural, biological and physical properties.


Selected Publications:

  1. “Broadly Applicable Synthesis of 1,2,4,5-Tetraoxanes” Prasanta Ghorai and Patrick H. Dussault, Org. Lett. 2009, 11, 213-216.

  2. “NG-Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H2 Receptor Agonists” Anja Kraus,§ Prasanta Ghorai,§ Tobias Birnkammer, David Schnell, Sigurd Elz, Roland Seifert, Stefan Dove, Günther Bernhardt, and Armin Buschauer, ChemMedChem. 2009, 4 (2),232-240. (§ authors contributed equally)

  3. “A mild and efficient Re(VII)-catalyzed synthesis of 1,1-dihydroperoxide” Prasanta Ghorai and Patrick H. Dussault, Org. Lett. 2008, 10, 4577-4579.

  4. “Synthesis of Spiro-bisperoxyketals” Prasanta Ghorai, Patrick H. Dussault, and Chunhua Hu, Org. Lett. 2008, 10, 2401-2404.

  5. “Acylguanidines as Bioisosteres of Guanidines: NG-Acylated Imidazolylpropylguanidines, a New Class of Histamine H2 Receptor Agonists”  Prasanta Ghorai, Anja Kraus, Max Keller, Carsten Götte, Patrick Igel, Günther Bernhardt, Manfred Zabel, Stefan Dove, Sigurd Elz, Roland Seifert, Armin Buschauer, J. Med. Chem., 2008, 51, 7193-7204.

  6. “Constitutive activity and ligand selectivity of human, guinea pig, rat, and canine histamine H2 receptors” Hendrik Preuss, Prasanta Ghorai, Anja Kraus, Stefan Dove, Armin Buschauer, Roland Seifert, J Pharmacol Exp Ther, 2007, 321, 983-995.

  7. “Mutations of Cys-17 and Ala-271 in the human histamine H2 receptor determine the species selectivity of guanidine-type agonists and increase constitutive activity” Hendrik Preuss, Prasanta Ghorai, Anja Kraus, Stefan Dove, Armin Buschauer, Roland Seifert, J Pharmacol Exp Ther, 2007, 321, 975-982.

  8. “Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated imidazolylpropylguanidines” Sheng-Xue Xie, Prasanta Ghorai, Qi-Zhuang Ye, Armin Buschauer, Roland Seifert,J Pharmacol Exp Ther, 2006, 317, 139–146.

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