INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH BHOPAL

 

Name: Dr. Himanshu Kumar
Designation: Assistant Professor
Department: Biology
E-Mail: hkumar@iiserbhopal.ac.in
Phone: +91-755-4092307
Fax: +91-755-4092392

Academic Profile:

  • Assistant Professor (July 2010-), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.

  • Adjunct Associate Professor. (March 2010-),World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.

  • JSPS Post-doctoral Fellow. (April 2008-March 2010), Laboratory of Host Defense, World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.

  • Ph.D.[April 2004-March 2008 as Japanese Government Fellow (MEXT Fellow)], Immunobiology, Graduate School of Medicine, Osaka University, Japan with Professor. Shizuo Akira.

Awards and Fellowships:

  • Awarded Ramanujan Fellowship from Department of Science and Technology, Government of India (July 2010-).

  • Awarded Kishimoto Foundation Fellowship from WPI Immunology Frontier Research Center, Osaka University (April 2010-June 2010).

  • Awarded Japan Society for the Promotion of Science (JSPS) Post-doctoral Fellowship from Government of Japan (April 2008-March 2010).

  • Awarded Japanese Government Scholarship (MEXT) from Government of Japan (April 2003-March 2008) for pursuing doctoral thesis.

Research Interest:

  • To understand the molecular mechanisms of host-pathogen interactions.


Selected Publications:

  1. Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T, Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal b-glucan, Journal of Immunology 2009 Dec 15;183(12):8061-8067.

  2. Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S, Poly I:C-induced activation of NK cells by CD8a+ dendritic cells via the IPS-1 and TRIF-dependent pathways. Journal of Immunology 2009 Aug 15;183(4):2522-2528.

  3. Kumar H, Kawai T, Akira S, Pathogen Recognition in the Innate Immune Response.Biochemical Journal 2009 Apr 28;420(1):1-16.

  4. Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, Akira S, Cutting Edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-a production in plasmacytoid dendritic cells.Journal of Immunology 2009 Apr 1;182(7):3960-3964.

  5. Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S. Tank-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.Nature2008, Feb 7; 451 725-729.

  6. Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S. Cutting Edge: Cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses.Journal of Immunology 2008, Jan 15; 180(2) 683-687.

  7. Jung A,Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, Akira S. Lymphocytoidchoriomeningitis virus activates plasmacytoid dendritic cells and induces cytotoxic T cell response via MyD88.Journal of Virology 2008, 82(1): 196-206.

  8. Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S. Differential role of TLR- and RLR-signaling in innate and adaptive immune response to influenza A virus infection and vaccination.Journal of Immunology2007 Oct 1;179(7):4711-4720.

  9. Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Kawai T, Akira S. Alveolar macrophages are primary interferon-α producer in response to lung RNA virus infection. Immunity 2007 Aug:27(2):240-252.

  10. Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, Akira S, Savan R, Echo DV, Fitzgerald KA, Young HA, Ching LM, and Vogel SN. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis.Journal of Experimental Medicine2007 Jul 9;204(7):1559-1569.

  11. Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O and Akira S. Essential role of IPS-1 in innate immune responses against RNA viruses. Journal of Experimental Medicine2006 Jul 10; 203(7):1795-1803.

  12. Takahashi K,Kawai T, Kumar H, Sato S, Yonehara S and Akira S. Cutting Edge: Roles of Caspase-8 and Caspase-10 in Innate Immune Responses to Double-stranded RNA.Journal of Immunology. 2006 Apr 15; 176(8):4520-4524.

  13. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.Nature Immunology. 2005 Oct;6(10):981-988.

  14. Kumar H, Takeda K and Akira S (2004) Toll-like Receptors, Encyclopedia of Biological Chemistry (W.J. Lennarz& M.D. Lane, eds), Elsevier, Oxford, Vol.4, pp. 190-194

  15. Kumar H, Malhotra D, Goswami S, Bamezai R. How far have we reached in tuberculosis vaccine development?Critical Reviews in Microbiology. 2003;29 (4):297-312.

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