INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH BHOPAL

 

Name: Dr. Himanshu Kumar
Designation: Assistant Professor
Department: Biology
E-Mail: hkumar@iiserb.ac.in
Phone: +91-755-4092307
Fax: +91-755-4092392

Academic Profile:

  • Assistant Professor (July 2010-), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.

  • Adjunct Associate Professor. (March 2010-),World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.

  • JSPS Post-doctoral Fellow. (April 2008-March 2010), Laboratory of Host Defense, World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.

  • Ph.D.[April 2004-March 2008 as Japanese Government Fellow (MEXT Fellow)], Immunobiology, Graduate School of Medicine, Osaka University, Japan with Professor. Shizuo Akira.

Awards and Fellowships:

  • Awarded Ramanujan Fellowship from Department of Science and Technology, Government of India (July 2010-).

  • Awarded Kishimoto Foundation Fellowship from WPI Immunology Frontier Research Center, Osaka University (April 2010-June 2010).

  • Awarded Japan Society for the Promotion of Science (JSPS) Post-doctoral Fellowship from Government of Japan (April 2008-March 2010).

  • Awarded Japanese Government Scholarship (MEXT) from Government of Japan (April 2003-March 2008) for pursuing doctoral thesis.

Research Interest:

  • To understand the molecular mechanisms of host-pathogen interactions.


 Research Publications:

  1. Kumar H*, Kawai T, Akira S, Pathogen Recognition by Innate Immunity, International Reviews in Immunology, 2011(*corresponding author) (In Press).
  2. Kumar H, Pandey S, Zou J, Kumagai Y, Takahashi K, Akira S, Kawai T, NLRC5 deficiency does not influence cytokine induction by virus and bacteria, Journal of Immunology 2011 10.4049/jimmunol.1002094.
  3. Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S, The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular, Immunity 2010Nov 24;33(5):765-76.
  4. Kumar H, Takeuchi O, Akira S (2010) Toll-like Receptors, Encyclopedia of Biological Chemistry (W.J. Lennarz & M.D. Lane, second eds), Elsevier, Oxford, (In press)
  5. Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T, Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan, Journal of Immunology 2009 Dec 15;183(12):8061-8067.
  6. Kumar H, Kawai T, Akira S, Toll-like receptors and natural immunity, Biochemical and Biophysical Research Communications 2009 Oct 30;388(4):621-625.
  7. Kumar H, Kawai T, Akira S, Pathogen Recognition in the Innate Immune Response. Biochemical Journal 2009 Apr 28;420(1):1-16.
  8. Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S, Poly I:C-induced activation of NK cells by CD8alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways. Journal of Immunology 2009 Aug 15;183(4):2522-2528.
  9. Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, Akira S, Cutting Edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-alpha production in plasmacytoid dendritic cells. Journal of Immunology 2009 Apr 1;182(7):3960-3964.
  10. Lee PY, Kumagai Y, Li Y, Takeuchi O, Yoshida H, Weinstein J, Kellner ES, Nacionales D, Barker T, Kelly-Scumpia K, Rooijen N, Kumar H, Kawai T, Satoh M, Akira S, Reeves WH, TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. Journal of Experimental Medicine 2008, Dec 22; 205(13): 2995-3006.
  11. Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S. Tank-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 2008, Feb 7; 451 725-729.
  12. Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S. Cutting Edge: Cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses. Journal of Immunology 2008, Jan 15; 180(2) 683-687.
  13. Jung A, Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, Akira S. Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces cytotoxic T cell response via MyD88. Journal of Virology 2008, 82(1): 196-206.
  14. Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S. Differential role of TLR- and RLR-signaling in innate and adaptive immune response to influenza A virus infection and vaccination. Journal of Immunology 2007 Oct 1;179(7):4711-4720.
  15. Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S. Enhanced TLR-mediated NF-IL6-Dependent Gene Expression by Trib1 Deficiency. Journal of Experimental Medicine 2007 Sep 3;204(9):2233-2239.
  16. Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Kawai T, Akira S. Alveolar macrophages are primary interferon-αlpha producer in response to lung RNA virus infection. Immunity 2007 Aug:27(2):240-252.
  17. Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, Akira S, Savan R, Echo DV, Fitzgerald KA, Young HA, Ching LM, and Vogel SN. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis. Journal of Experimental Medicine2007 Jul 9;204(7):1559-1569.
  18. Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S. VP1686, a Vibrio type III secretion protein, induces toll-likereceptor-independent apoptosis in macrophage through NF-kappaB inhibition. Journal of Biological Chemistry 2006 Dec 1;281(48):36897-36904.
  19. Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S. Essential role of IPS-1 in innate immune responses against RNA viruses. Journal of Experimental Medicine 2006 Jul 10; 203(7):1795-1803.
  20. Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Cutting Edge: Roles of Caspase-8 and Caspase-10 in Innate Immune Responses to Double-stranded RNA. Journal of Immunology. 2006 Apr 15; 176(8):4520-4524.
  21. Malhotra D, Darvishi K, Lohra M, Kumar H, Grover C, Sood S, Reddy BSN, Bamezai R. Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population. European Journal of Human Genetics 2006 Apr; 14(4):438-442.
  22. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nature Immunology. 2005 Oct;6(10):981-988.
  23. Kumar H, Takeda K, Akira S (2004) Toll-like Receptors, Encyclopedia of Biological Chemistry (W.J. Lennarz & M.D. Lane, eds), Elsevier, Oxford, Vol.4, pp. 190-194.
  24. Kumar H, Malhotra D, Goswami S, Bamezai R. How far have we reached in tuberculosis vaccine development? Critical Reviews in Microbiology. 2003;29 (4):297-312.

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